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接触敏感化的趋势,结果,以及来自以色列接触性皮肤炎诊所的含义
Dan Slodownik1,2, Jonathan Bar1,2, Danny Daniely1,2
1Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Contact dermatitis
|February 18, 2024
概括
以色列的过敏原敏感化趋势显示,过去二十年来,几种常见的过敏原的频率正在下降. 甲基chloroisothiazolinone/甲基isothiazolinone (MCI/MI) 和2-hydroxyethyl methacrylate-2 (HEMA) 仍然是需要监管的重大问题.
科学领域:
- 皮肤病学 皮肤病学
- 过敏学 过敏学
- 流行病学 流行病学
背景情况:
- 过敏原敏感化模式在地理位置上有所不同,并且随着时间的推移而演变.
- 对以色列人口的特征趋势提供了对区域差异的洞察.
研究的目的:
- 分析过去二十年来以色列过敏原敏感化趋势.
- 将以色列数据与欧洲和北美接触性皮肤炎登记处进行比较.
- 在欧洲基线系列 (EBS) 和欧洲基线系列 (OEBS) 外的额外系列中识别显著的过敏原.
主要方法:
- 对特拉维夫2086名患者 (2019-2022) 的贴片检测结果的分析.
- 与欧洲和北美注册表进行比较.
- 与以色列20年前进行的2156次补丁测试结果进行比较.
主要成果:
- 38.6%的患者对欧洲基线系列过敏原表现出敏感性,其中硫酸盐,香料混合物I和MCI/MI是最常见的.
- 香料混合物I,甲,二酸盐等的敏感化频率在过去二十年中显著下降.
- 与北美和欧洲注册表相比,以色列队列的总体敏感率较低.
结论:
- 甲基chloroisothiazolinone/methylisothiazolinone (MCI/MI) 和2-hydroxyethyl methacrylate-2 (HEMA) 是普遍存在的过敏原,需要监管机构关注.
- 某些过敏原 (NIPPD,,酸乳,布德索尼德) 具有较低的敏感性,可能需要重新考虑将其列入基线.
- 需要警的是 OEBS 过敏原,如 氨基醇 和 夸特 15; 降低的敏感性可能表明,早期口服暴露对以色列人的保护作用.
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