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超越承诺:探索纳米粒子在生物系统中的复杂相互作用

Yunxia Ji¹, Yunqing Wang², Xiaoyan Wang³

¹CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou 256603, China.

Journal of hazardous materials

|February 18, 2024

概括

纳米粒子可以通过进入人体并破坏细胞功能来危害人类健康. 了解纳米粒子毒性是开发更安全的纳米技术应用的关键.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
纳米技术纳米技术

背景情况:

纳米粒子的应用是有前途的,但也引发了环境和健康方面的担忧.
纳米粒子可以通过各种途径进入人体,并前往遥远的器官.
细胞进入可以导致结构和功能损伤,影响生理系统.

研究的目的:

探索影响生物系统中纳米粒子行为的因素.
提供纳米粒子对细胞,器官和生理系统的影响的概述.
讨论不利纳米粒子效应背后的潜在机制.

主要方法:

关于纳米粒子与生物系统相互作用的文献综述.
分析影响纳米粒子生物分布和细胞吸收的因素.
综合关于纳米粒子诱导毒性的当前知识.

主要成果:

纳米粒子的大小,形状,电荷和组成都会影响它们的生物命运.
细胞中断包括膜损伤,线粒体损伤和改变的核结构.
系统性影响可能来自于干扰细胞信号通路.

结论:

纳米粒子与生物系统的相互作用是复杂和多方面的.
了解纳米粒子毒性对于风险评估和安全技术开发至关重要.
需要进一步的研究来阐明纳米粒子引起的特定危害机制.

关键词:

生物系统是生物系统.复杂的相互作用相互作用.纳米颗粒是如何形成的生理系统生理系统.有毒效应有毒效应有毒效应

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