增长分化因子15与冠状动脉样硬化的存在和严重程度之间的关联
Emrah Ozdemir1, Berna Stavileci1, Bahar Ozdemir2
1Department of Cardiology, Biruni University Faculty of Medicine, Küçükçekmece, Istanbul, Turkey.
Advances in medical sciences
|February 18, 2024
概括
增长差异化因子15 (GDF-15) 与冠状动脉疾病 (CAD) 的严重程度有关. 升高的GDF-15水平独立地预测了稳定的CAD患者的CAD程度和复杂性.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 蛋白质组学是指蛋白质组学.
背景情况:
- 增长差异化因子15 (GDF-15) 是一种应激反应的细胞因子.
- 在各种心血管疾病中,GDF-15水平升高,包括冠状动脉疾病 (CAD),心房动和心力衰竭.
研究的目的:
- 调查GDF-15水平与CAD的程度和严重程度之间的关联.
- 评估GDF-15作为稳定的CAD患者中CAD的潜在预测因子.
主要方法:
- 纳入了129名患有稳定的CAD,正在接受冠状动脉血管造影的患者.
- 计算了SYNTAX和SYNTAX II分数,以评估CAD的严重程度.
- 根据平均GDF-15值,患者被分为高GDF-15组和低GDF-15组.
主要成果:
- 在患有CAD的患者中,GDF-15水平显著更高 (p < 0.001).
- 高GDF-15水平与较高的SYNTAX和SYNTAX II分数有很强的相关性 (p < 0.001).
- 多变量分析确定GDF-15是CAD的独立预测因子.
结论:
- GDF-15是CAD的一个独立预测器.
- 根据SYNTAX,SYNTAX II PCI和SYNTAX II CABG得分,GDF-15水平与CAD的严重程度有显著的相关性.
相关概念视频
TGF - β Signaling Pathway
7.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.4K
Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Role of Hematopoietic Growth Factors
1.4K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.4K


