初级抗脂综合征损伤累积的危险因素:一个回顾性单中心队列研究
Ariela Hoxha1, Nicola Perin1, Marco Lovisotto1
1Internal Medicine Unit, Thrombotic and Hemorrhagic Center, Department of Medicine, University of Padua, Italy.
Journal of autoimmunity
|February 18, 2024
概括
抗脂综合征 (APS) 患者经常经历损伤累积,即使使用抗凝剂治疗. 微血管病变和非标准表现明显增加了这种损伤的风险.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 抗脂综合征 (APS) 与高频率的复发事件有关,尽管抗凝剂治疗.
- 这些反复发生的事件可能会导致严重的损害累积和降低患者的生活质量.
研究的目的:
- 为了确定APS患者损伤累积的危险因素.
- 为了确定与增加损害累积相关的特定APS子集.
主要方法:
- 对282名APS患者进行了回顾性单中心研究.
- 后续分析以评估损害累积,定义为持续的器官/组织损伤或永久性损失.
- 评估二次终点,包括早期器官损伤和死亡率.
主要成果:
- 损伤累积发生在28.4%的APS患者中,52.5%的患者在发病后六个月内发生损伤.
- 神经精神病参与是最常见的 (38.8%),其次是周围血管病变和脏参与.
- 微血管病变 (OR 4.9) 和非标准表现 (OR 3.8) 是损伤累积的独立风险因素,分别增加了5倍和4倍的风险.
结论:
- 在APS患者中,损伤累积的频率更高.
- 微血管病变和非标准表现被确定为APS中损害累积的独立风险因素.
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