较低的血清费里水平与衰老的认知表现较差有关
Marisel Rosell-Díaz1, Elena Santos-González1, Anna Motger-Albertí1
1Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain; Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona, Spain; CIBER Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain.
The journal of nutrition, health & aging
|February 18, 2024
概括
血清费里 (SF) 水平与更好的认知功能有关,特别是在老年男性中. 低SF可能表明需要补充铁来提高认知能力.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 放射学 放射学是一门学科.
背景情况:
- 铁对神经发生和神经递质合成等大脑功能至关重要.
- 血清铁素 (SF) 作为身体铁储量的可靠指标.
- 认知能力下降是老年人群的一个重大问题.
研究的目的:
- 为了研究血清费里水平与不同年龄组的认知功能之间的关联.
- 通过R2*MRI测量的大脑铁含量与血清费里水平之间的关系.
主要方法:
- 分析了来自三项横截面观察性研究 (衰老图像学,健康图像学,IR0NMET) 的数据,涉及2176名参与者.
- 认知评估包括执行功能 (总数字跨度,语音口语流),语言 (语义口语流),注意力 (符号数字模式测试) 和记忆 (记忆绑定测试).
- 使用R2*磁共振成像 (MRI) 量化大脑铁含量.
主要成果:
- 在65岁及以上的个体中,更高的SF水平与总数字跨度,语音口语流性和语义口语流性得分的改善相关,特别是在男性中.
- 中年受试者也显示了SF水平和语义语言流之间的积极关联.
- 在男性中,SF水平与特定前脑区域的R2*值相反相关,表明脑铁含量较低,SF含量较高.
结论:
- 血清费里水平与认知表现有显著的积极关联.
- 补充铁可以作为一种潜在的治疗策略,用于提高老年人低SF水平的认知能力.
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