肝炎C病毒感染与冠状动脉和胸腔大动脉动脉样硬化相关
Chih-Wen Wang1, Chung-Feng Huang2, Ming-Lun Yeh2
1Division of Hepatobiliary, Department of Internal Medicine, Kaohsiung Medical University Hospital; School of Medicine and Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
型肝炎病毒 (HCV) 感染,特别是代谢综合征或肝纤维化,显著增加患冠状动脉和胸腔大动脉动脉样硬化的风险. 早期检测和管理对于预防HCV患者心血管并发症至关重要.
科学领域:
- 心血管医学 心血管医学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 冠状动脉和胸前大动脉化与主要的血管疾病如中风有关.
- 肝炎C病毒 (HCV) 感染是已知的代谢异常的风险因素,包括胰岛素抵抗和糖尿病.
- 感染HCV和动脉样硬化之间的联系需要进一步调查.
研究的目的:
- 探索C型肝炎病毒感染与冠状动脉和胸腔大动脉动脉样硬化的存在之间的关系.
- 评估代谢综合征和肝纤维化指标如何改变这种关联.
主要方法:
- 使用胸部计算机断层扫描 (Agatston分数) 量化了化.
- 代谢综合征的诊断是使用修改的成人治疗小组III标准.
- 评估了HCV感染状况,肝纤维化 (FIB-4,APRI) 和病毒载量 (抗HCV S/CO比率).
主要成果:
- 冠状病毒感染与动脉样硬化独立相关 (OR=2.75).
- 冠状病毒和代谢综合征的结合表明与动脉样硬化有显著的关联 (OR=2.65).
- 肝纤维化HCV (FIB-4或APRI) 或高抗HCVS/CO比率也表明动脉样硬化风险增加.
结论:
- 冠状病毒感染是冠状动脉和胸腔大动脉动脉样硬化的重要危险因素.
- 代谢综合征和肝纤维化指标加剧了这种风险.
- 抗HCV S/CO比率升高也与HCV患者的动脉样硬化有关.
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