相关实验视频

Updated: Jul 2, 2025

Generation of Alginate Microspheres for Biomedical Applications

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

通过封装在酸盐/酸盐纳米颗粒中,增强福可桑丁的稳定性和生物活性

Feuangthit Niyamissara Sorasitthiyanukarn¹, Chawanphat Muangnoi², Pranee Rojsitthisak¹

¹Metallurgy and Materials Science Research Institute, Chulalongkorn University, Bangkok 10330, Thailand; Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand.

International journal of biological macromolecules

|February 18, 2024

概括

酸盐和酸盐纳米颗粒有效地提供富可桑丁,增强其稳定性,生物可访问性和用于食品和医药的治疗性质.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药理学药理学是一个学科.

背景情况:

富可丁 (FX) 是一种海洋类胡卜素,具有显著的健康益处,但口服生物可用性较差.
开发有效的输送系统对于最大限度地发挥FX的治疗潜力至关重要.

研究的目的:

开发和优化酸盐-酸盐纳米颗粒 (ALG/CS-NP) 进行增强的富可桑 (FX) 输送.
评估FX载荷ALG/CS-NP的物理化学性质,稳定性和体外生物活性.

主要方法:

使用响应表面方法 (Box-Behnken设计) 来优化ALG/CS-NP的配方.
纳米粒子是通过油在水乳化和离子凝制成的.
描述包括尺寸,泽塔潜力,封装效率,稳定性,释放动力学和体外生物活性测试.

主要成果:

最佳配方实现了227nm的纳米粒子尺寸,35.3mV的泽塔电位和81.2%的封装效率.
充满FX的ALG/CS-NP表现出增强的稳定性,受控释放和改善的口服生物可访问性.
在体外观察到抗氧化,抗炎和抗癌活性显著增加.

结论:

酸 - 基托桑纳米颗粒是富可桑输送的有效载体.
这些纳米载体在营养保健品,功能性食品和药品中的应用方面表现有前途.
开发的系统增强了外汇货币的稳定性和生物活性,克服了其交付限制.

关键词:

阿尔金酸盐是一种酸盐.生物可访问性生物可访问性基托桑是一种酸盐.细胞毒性细胞毒性富可桑丁是一种富可桑丁 (fucoxanthin) 的成分.纳米颗粒纳米颗粒

更多相关视频

Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability

Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability

Published on: April 22, 2016

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

相关概念视频

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...