双醇和化双醇通过其破坏内皮氧化合成酶诱导内皮功能障碍
Chao Hu1, Liping Lu2, Chunyan Guo3
1Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
Environmental pollution (Barking, Essex : 1987)
|February 18, 2024
概括
这项研究表明,双A和双S增强了氧化 (NO) 的产生,而四双S则减少了它,在体外和体内不同影响了血管内皮功能.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管科学 心血管科学
背景情况:
- 像双醇这样的内分泌干扰化学物质 (EDC) 与心血管疾病有关.
- 在EDC引起的心血管风险背后的机制需要进一步研究.
- 内皮功能障碍是心血管疾病发病的一个关键因素.
研究的目的:
- 研究双和双对内皮功能的影响.
- 阐明对大动脉病理结构的影响,内皮氧化合成酶 (eNOS) 活性和氧化 (NO) 生产.
- 在人静脉内皮细胞 (HUVEC) 和C57BL/6小鼠中比较体外和体内效应.
主要方法:
- 对HUVEC和C57BL/6小鼠暴露于双A (BPA),双S (BPS) 和四双S (TBBPS).
- 测量氧化 (NO) 生产和eNOS酸化和活性.
- 大动脉转录组分析,以确定受影响的信号通路.
- 在小鼠中评估大动脉病理结构.
主要成果:
- 在体外和体内,BPA和BPS增加了NO的产生,而TBBPS显著抑制了它.
- BPA和BPS促进了eNOS的酸化和活性,而TBBPS则降低了它们.
- 暴露于TBBPS导致大动脉厚度增加,并诱导小鼠内皮功能障碍.
- 转录组分析表明",NO介导信号转导的调节"常常受到影响.
结论:
- 双和双不同影响血管内皮功能.
- 与BPA和BPS相比,TBBPS对内皮功能障碍和大动脉结构变化的风险更大.
- 这些发现突出了关于EDC暴露和血管健康的潜在公共卫生问题.
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