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在Mycobacterium avium中存在内在的克拉里素异阻力

Ai Ito¹, Yuta Nanjo², Chiaki Kajiwara³

¹Department of Respiratory Medicine, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan; Department of Microbiology and Infectious Disease, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

|February 18, 2024

概括

飞菌 (Mycobacterium avium) 表现出对澄素的内在异性耐药性,这解释了肺部疾病患者治疗失败的原因. 这种在体外和体内观察到的现象强调了进一步进行临床相关性研究的必要性.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

在健康的成年人中,Mycobacterium avium会导致肺部疾病.
克拉里斯罗米辛治疗失败甚至发生在敏感菌株中.

研究的目的:

调查临床治疗差异的原因与克拉里菌素.
在Mycobacterium avium中表征克拉里素耐受性和异阻力.

主要方法:

对M. avium群体进行克拉里素耐受性和异质抵抗性的分析.
确定M. avium和M. kansasii菌株的MIC和MBC.
在体内小鼠模型,以评估肺部同质体中的克拉里素耐药性.

主要成果:

所有的M. avium菌株都显示MBC/MIC比率≥8.8.
在体外和体内检测到M. avium的异性耐药亚群在MIC以上.
肺同质体显示出比体外更明显的克拉里思罗米辛耐药性.

结论:

飞菌 (Mycobacterium avium) 具有对克拉里菌素的内在异性耐药性.
这种异阻力可能解释临床失败,尽管在体外敏感性.
需要进一步的研究来将异体电阻与临床结果联系起来.

关键词:

对抗生素敏感性的敏感性克拉里斯罗米辛是什么意思克拉里斯罗米辛不同电阻的异质电阻这种细菌是Mycobacterium avium.肺部疾病肺部疾病耐火的耐火的耐火的

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