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在炎症性肠病患者中,COVID-19疫苗的长期有效性和持久性
Erica J Brenner1, Kimberly N Weaver2, Xian Zhang1
1Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
接种COVID-19疫苗对大多数炎症性肠病 (IBD) 患者提供强有力的保护,即使是那些服用免疫抑制剂的患者. 建议在这个脆弱人群中进行增强注射,以保持免疫反应和耐久性.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 接受免疫抑制剂的炎症性肠病 (IBD) 患者可能对COVID-19疫苗产生麻木的血清反应.
- 了解IBD的长期疫苗有效性对于管理感染风险至关重要.
研究的目的:
- 评估IBD成年人的COVID-19疫苗接种后的SARS-CoV-2感染率.
- 确定影响SARS-CoV-2感染风险和抗体持久性的因素.
- 评估IBD患者对COVID-19疫苗接种的幽默免疫反应的持久性.
主要方法:
- 在COVID-19免疫接种后,对1869名IBD成年人的前性队列研究.
- 在接种疫苗后12周和52周,分析与SARS-CoV-2感染和抗体水平相关的因素.
- 接收器运行特征曲线分析以确定保护性抗体值.
主要成果:
- 43%的参与者在接种疫苗后感染了COVID-19,大多数感染是轻微的,<1%需要住院治疗.
- 高龄和使用皮质类固醇与SARS-CoV-2感染风险降低有关.
- 在52周,98%的人保持可检测的抗体水平;抗TNF治疗与较低的抗体水平有关.
结论:
- 在大多数患有IBD的成年人中,COVID-19疫苗接种提供了强大而持久的保护性免疫反应.
- 易受IBD感染的人群,包括老年人和皮质类固醇使用者,从疫苗接种中获益显著.
- 对于患有IBD的患者来说,COVID-19增强疫苗接种有利于维持幽默免疫力.
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