生命早期的认知能力和成年期的抑郁风险:系统性审查和元分析
Emily L Ball1, Laura Morillo1, Elizabeth Poyner1
1Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Journal of affective disorders
|February 18, 2024
概括
这项研究发现,儿童的认知能力与成人抑郁风险之间没有联系. 进一步的研究应该探索影响这种关系的生命过程因素.
科学领域:
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
- 流行病学 流行病学
背景情况:
- 认知能力和抑郁症之间的关系已经确立,但它的方向性仍然不清楚.
- 在抑郁症发作之前调查儿童的认知能力可以澄清其预测作用.
- 本系统性审查和元分析涉及早期认知技能与晚期抑郁症之间的关联.
研究的目的:
- 系统地审查和元分析童年评估的认知能力与成年后患抑郁症的风险之间的关联.
- 为了确定儿童的认知功能是否预测成人抑郁症.
- 探索这个协会的潜在主持人.
主要方法:
- 在2024年1月之前,对五个数据库进行了全面的搜索.
- 包括的研究评估了18岁以下个体的认知能力和成年人的抑郁症.
- 一个随机效应的元分析从18篇文章 (19个队列) 中汇集了相关系数,并进行了子组分析以解决异质性问题.
主要成果:
- 对20个样本人群的元分析 (N=45,786) 显示,儿童认知能力和成人抑郁症之间没有显著的关联 (r=-0.04,95% CI=-0.09到0.01,p=0.09).
- 亚组分析表明,评估时的年龄,随访时间,抑郁症测量类型和性别并没有显著改变观察到的关联.
- 大多数被纳入的研究被评估为具有中等偏差风险.
结论:
- 这一元分析得出的结论是,童年认知能力与成年期抑郁症风险之间没有明显的关联.
- 局限性包括仅限于英语研究的文献搜索和跨研究的共同变量调整的异质性.
- 未来的纵向,人口层面的研究应该旨在控制更广泛的生命过程中介质,包括人口和环境因素.
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