一个系统的审查和对长期使用抗生素对认知结果的影响的元分析

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Yongqin Ye¹, Hor Yee Kimberley Tong², Wai Hong Chong¹

¹Faculty of Medicine, Medical Sciences Division, Macau University of Science and Technology, Avenida da Harmonia, Praia Park, Coloane, 999078, Macao SAR, China.

Scientific reports

|February 18, 2024

概括

长期使用抗生素与较差的认知结果有关,特别是在没有先前认知障碍的个体中. 需要进一步的研究来理解这种肠-大脑轴连接.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

抗生素对于治疗感染至关重要,但可以破坏肠道微生物群,可能影响大脑功能.
由抗生素诱导的肠道微生物群失生症可能会损害肠-大脑轴,影响认知健康.

研究的目的:

系统地审查和元分析长期抗生素暴露对认知结果的影响.
探索成人和儿科患者之间抗生素对认知影响的潜在差异.
为了确定抗生素使用是否影响具有或没有先前存在的认知障碍的个体的认知.

主要方法:

一个系统的审查和元分析,遵循PRISMA指南.
搜索了主要的数据库 (PubMed,科学网,Embase,Cochrane图书馆,Scopus) 的英语出版物,直到2023年3月.
包括16项比较抗生素使用与安慰剂/无抗生素的研究,不包括病例报告和动物/体外研究.

主要成果:

抗生素使用与认知结果明显恶化有关 (综合效应估计: -0.11,P < 0.00001).
这种关联在成人和儿科亚组中一致.
抗生素治疗并没有使现有障碍患者的认知能力恶化,但与没有先前障碍患者的未来认知表现较差有关.

结论:

抗生素的使用可能会对认知表现产生负面影响,特别是在没有先前认知缺陷的个体中.
这些发现强调了需要进行精心设计的研究,以进一步阐明抗生素对认知和肠-大脑轴的影响.

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