数字连接测试A和数字符号测试的基于回归的中国规范,用于诊断最小肝脑病变
Peng Zhang1,2, Danan Gan1,3, Xiaoling Chi4
1Institute of Liver Disease, Beijing University of Chinese Medicine, Beijing, China.
Scientific reports
|February 18, 2024
概括
在中国,标准化神经心理测试用于最小肝脑病变 (MHE) 是使用基于回归的规范开发的. 在肝硬化患者中发现了MHE的显著患病率,特别是那些儿童-皮格分类较差的患者.
科学领域:
- 神经科学是一个神经科学.
- 肝病学 肝病学是一种肝病学.
- 心理学 心理学 心理学
背景情况:
- 在中国,最小肝脑病变 (MHE) 的检测依赖于数字连接测试A (NCT-A) 和数字符号测试 (DST),这些测试对中国人口缺乏标准化规范.
- 标准化对于在肝硬化患者中准确的MHE诊断和管理至关重要.
研究的目的:
- 在中国人口中为NCT-A和DST建立人口调整规范.
- 使用这些测试,开发一种标准化的方法来检测MHE在肝硬化患者中.
主要方法:
- 一项多中心的横截面研究,涉及648名健康对照组和1665名肝硬化患者.
- 基于回归的程序被用来开发NCT-A和DST的年龄,性别和教育调整的规范.
- 在肝硬化患者中诊断出MHE,同时出现NCT-A和DST异常结果.
主要成果:
- 为NCT-A (标准Z ≤1.64) 和DST (标准Z ≥-1.64) 建立了预测方程和Z分数.
- 肝硬化患者中MHE的患病率为8.89%.
- 更糟糕的儿童-皮格分类被确定为MHE的显著风险因素 (P = 0.002,OR = 2.389).
结论:
- 针对NCT-A和DST的基于回归的规范数据已成功开发用于在中国检测MHE.
- 很大一部分中国肝硬化患者患有MHE,肝功能较差 (Child-Pugh分类较差) 患者的风险更高.
- 这些标准化规范将改善中国的MHE诊断和患者管理.
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