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Updated: Jul 2, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
11:02

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

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单氨基酸链接剂通过条件释放使极强的小分子药物结合物成为可能

Yan Zheng1, Ruolin Xu1, Hong Cheng1

  • 1Department of Pharmacy, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|February 19, 2024
PubMed
概括

研究人员开发了一种简单的单氨基酸链接器,用于小分子药物联合体 (SMDC). 这种链接器增强了药物输送,显示出强大的抗瘤作用和针对癌症治疗的稳定性.

关键词:
在 Fc 移植.在MMAF中,MMAF是MMAF.在SMDC-Fcc.这是一种auristatin.卡瑟普辛B B的情况可以切割的链接器.叶酸是一种叶酸.小分子连接体的小分子连接体.

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