Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A multifunctional kapok cellulose nanofiber/MWCNT/Fe<sub>3</sub>O<sub>4</sub> flexible multilayer film for electromagnetic interference shielding.

International journal of biological macromolecules·2026
Same author

Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting m<sup>6</sup>A-dependent decay of cytosolic mitochondrial mRNAs.

Science advances·2026
Same author

Mussel-inspired molecular strategy for ultrasensitive detection of multiple chiral molecules.

Analytica chimica acta·2026
Same author

Quantitative proteomics identifies GntR as a novel potential DIVA antigen for bovine brucellosis.

Applied microbiology and biotechnology·2026
Same author

Synergistic antibacterial effects and metabolomic insights in <i>Cyperus esculentus</i> L. leaf-stem extracts against <i>Staphylococcus aureus</i>.

Frontiers in microbiology·2026
Same author

Bioadhesive and hemostatic microneedles integrated with NIR-responsive Ti<sub>3</sub>C<sub>2</sub>/CeO<sub>2</sub> heterojunction nanozymes for accelerated diabetic wound healing.

Theranostics·2026

相关实验视频

Updated: Jul 2, 2025

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

12.8K

特里斯功能化的多氧和二甲基介导的抗瘤疗效涉及多个细胞死亡途径.

Lihong Chen1, Zijia Zhao2, Rominah Onintsoa Diarimalala2

  • 1Institute of POM-based Materials, New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan, 430068, Hubei, PR China.

Chemistry & biodiversity
|February 19, 2024
PubMed
概括

聚氧甲酸盐 (POMs) 作为低成本的癌症化疗剂显示出希望. 一种特定的 {V4W2} POM 通过诱导多种细胞死亡途径,表现出显著的抗瘤活性,这表明其具有广泛的潜力.

关键词:
聚氧甲酸盐是多氧甲酸盐的一种.它具有抗瘤活性.细胞死亡途径的细胞死亡途径.移民 移民 迁移 迁移它们的扩散和扩散.治疗指数 治疗指数

更多相关视频

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

57.7K
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.1K

相关实验视频

Last Updated: Jul 2, 2025

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

12.8K
Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

57.7K
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.1K

科学领域:

  • 无机化学 无机化学
  • 材料科学 材料科学 材料科学
  • 癌症研究 癌症研究

背景情况:

  • 聚氧甲酸盐 (POMs) 是具有癌症化疗潜力的低成本无机化合物.
  • 带有混合添加原子的林德奎斯特型POM为治疗应用提供可调节的特性.

研究的目的:

  • 合成和评估新型林德奎斯特型POMs的抗瘤活性.
  • 为了比较POMs与已知化疗药物如5-甲 (5-FU) 和gemcitabine的疗效.
  • 研究各种癌症细胞系中POM诱导的细胞死亡机制.

主要方法:

  • 合成了四个Lindqvist类型的POMs与混合添加原子.
  • MTT/CCK-8,殖民地形成和伤口愈合试验,以评估细胞毒性和抗增殖/迁移效应.
  • 流式细胞计,qRT-PCR和西式斑点检测用于分析细胞死亡途径 (细胞亡,自死,死细胞亡,热细胞亡).

主要成果:

  • {V4W2} POMs在正常细胞中表现出可接受的细胞毒性,并在A549,HeLa和MCF-7癌细胞系中显著抑制增殖和迁移.
  • 具有R=-CH2OH的{V4W2} POM显示了最有利的治疗指数.
  • POM治疗诱导了亡,并激活了多种细胞死亡途径,包括自,亡和亡.

结论:

  • 合成的多氧,和酸POMs具有显著的抗瘤潜力.
  • 具有R=-CH2OH的{V4W2} POM是广泛抗癌药物开发的有希望的候选者.
  • POMs激活多种细胞死亡机制,为癌症化疗提供了多方面的方法.