用胆盐丰富的纳米颗粒与未丰富的纳米颗粒:它们的物理化学特性和释放模式的比较
Marjan Emzhik1, Amirsajad Qaribnejad1, Azadeh Haeri1,2
1Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pharmaceutical development and technology
|February 19, 2024
概括
胆盐增强纳米粒子的特性,如尺寸和稳定性. 了解这些影响对于设计有效的药物输送纳米载体至关重要.
科学领域:
- 制药纳米技术 制药纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 胆盐具有固有的稳定性,使其适合纳米粒子制备.
- 纳米颗粒的物理化学特性显著影响它们的生物命运,有效性和毒性.
研究的目的:
- 审查关于在纳米载体制造中使用胆盐的文献.
- 阐明胆盐对纳米粒子物理化学特性的影响.
主要方法:
- 详细介绍基于胆汁盐的纳米载体制剂的科学文章的综合评论.
- 分析报告的关于纳米粒子特性受胆盐影响的数据.
主要成果:
- 胆盐可以显著改变纳米粒子的物理化学性质,包括捕获效率,粒子大小,多分散度指数和泽塔潜力.
- 胆汁盐的结合会影响各种纳米载体的释放特征和稳定性,如脂质体和阴质体.
结论:
- 胆盐为修改纳米载体特性提供了有价值的工具.
- 利用胆汁盐的潜力是开发针对药物输送应用的优化纳米载体的关键.
相关概念视频
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
208
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
208
01:22Factors Influencing Drug Absorption: Physicochemical Parameters
274
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
274