用于光子放射治疗的虚拟未增强的双能计算断层扫描:对剂量分配和基于形束计算断层扫描的位置验证的影响
Maryam Afifah1, Marloes C Bulthuis2, Karin N Goudschaal2
1Amsterdam UMC, Location Vrije Universiteit, Department of Radiation Oncology, De Boelelaan 1118, Amsterdam, the Netherlands.
Physics and imaging in radiation oncology
|February 19, 2024
概括
双能计算机断层扫描 (DECT) 的虚拟无增强图像 (VUE) 提供了可比的剂量分布和在妇科癌症放射治疗中改进的形光束CT (CBCT) 注册. 这种技术通过实现自动化骨注册来增强图像导向放射治疗 (IGRT).
科学领域:
- 医疗成像医学成像
- 辐射瘤学 辐射瘤学
- 计算机断层扫描 (CT) 是一种计算机断层扫描.
背景情况:
- 双能计算机断层扫描 (DECT) 的虚拟无增强图像 (VUE) 旨在消除对比前扫描或对比增强结构 (CES) 手动抑制的需要.
- 在CES以外的高密度结构中,VUE算法降低了CT强度,可能简化了放射治疗工作流程.
研究的目的:
- 评估VUE对妇科瘤放射治疗工作流程的影响.
- 为了比较VUE和对比增强CT (CECT) 图像之间的剂量分布和基于圆光束CT (CBCT) 的位置验证.
主要方法:
- 14名妇科患者接受了CET模拟.
- CT图像被重建为CECT和VUE.
- 卷度调制弧线疗法 (VMAT) 计划在VUE上使用CET和VUE查找表 (LUT) 重新计算.
- 马分析评估了3D剂量分布,CBCT注册使用Chamfer匹配进行.
主要成果:
- 规划目标体积 (PTV) 和风险器官 (OAR) 剂量参数显示CET和VUE之间达成0.36%的一致性.
- 一个专门的VUE LUT实现了100%的马传导率.
- 与CECT相比,基于VUE的CBCT注册显示出类似的转换和旋转,精度提高,注册不足较少.
结论:
- 在放射治疗工作流程中,VUE成像是可行的,它提供了与CECT相似的剂量分布.
- VUE改善了CBCT注册结果,实现了自动化骨注册,并减少了图像引导放射治疗 (IGRT) 中观察者之间的变异性.
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