氧-寡糖化合物通过向丰富Bifidobacterium来改善功能性便秘
Wanya Yi1,2, Qinyue Wang1,3, Yuzheng Xue4
1Department of Nutrition Affiliated Hospital of Jiangnan University Wuxi China.
Food science & nutrition
|February 19, 2024
概括
氧-寡糖化物 (XOS) 和果-寡糖化物 (FOS) 在改善功能性便秘方面表现有前途. 特别是在较低剂量时,XOS有效地增强了像Bifidobacterium这样的肠道细菌,导致症状缓解而没有副作用.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 功能性便秘 (FC) 显著影响患者的生活质量.
- 肠道微生物群的改变与FC的病理生理学有关.
- 调节肠道微生物群的饮食干预正在被探索为FC管理.
研究的目的:
- 为了研究-糖 (XOS) 和果糖-糖 (FOS) 补充剂在改善功能性便秘症状中的有效性.
- 评估XOS和FOS对FC患者肠道微生物群结构和功能的影响.
- 为了比较不同剂量的XOS和FOS的有效性和副作用概况.
主要方法:
- 一项随机,双盲,安慰剂对照试验与FC患者进行.
- 参与者每天服用XOS (3,5,10克),FOS (10,20克) 或安慰剂 (5克) 一个月.
- 胃肠功能使用布里斯托尔便形式量表 (BSFS) 和克利夫兰诊所便秘评分 (CCCS) 进行评估. 使用PAC-QoL来评估生活质量. 通过16S rRNA测序分析了肠道微生物群的变化.
主要成果:
- 与FOS相比,XOS补充剂,特别是在较低剂量的情况下,显著丰富了Bifidobacterium.
- 接受XOS治疗的患者表现出便秘症状明显改善.
- 在使用XOS补充剂时,没有报告过腹或气等重大副作用.
- 虽然个体细菌变化与症状改善相关,但整体肠道菌群结构基本保持不变.
结论:
- 用XOS和FOS补充饮食可以改善功能性便秘症状.
- XOS似乎是一个有希望的FC的益生菌剂,提供症状缓解和有利地调节Bifidobacterium水平.
- 对于管理功能性便秘来说,XOS提供了一个耐受良好的治疗选择.
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