生物系统中的活性氧物种:途径,相关疾病和潜在的抑制剂-一篇综述
Abdur Rauf1, Anees Ahmed Khalil2, Samir Awadallah3
1Department of Chemistry University of Swabi Anbar Pakistan.
Food science & nutrition
|February 19, 2024
概括
反应性氧物种 (ROS) 在细胞中发挥双重作用,作为信号分子或引起氧化应激. 本综述探讨了维护氧化还原稳态的ROS途径和抑制剂.
科学领域:
- 生物化学和分子生物学
- 细胞生理学 细胞生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 反应性氧物种 (ROS) 是正常细胞功能的组成部分,包括细胞信号传递,增殖和亡.
- 在ROS生产和抗氧化能力的不平衡导致氧化应激,涉及到各种病理.
- 维持细胞氧化还原平衡对于生物系统健康至关重要.
研究的目的:
- 审查和阐明由活性氧物种 (ROS) 调节的关键信号通路.
- 探索当前关于调节ROS途径的策略和抑制剂的文献.
- 提供ROS生成源及其生理相关性的全面概述.
主要方法:
- 关于ROS途径和抑制剂的科学文章的综合文献综述.
- 对信号级联的分析,包括NF-κB,MAPK,PI3K-Akt和Keap1-Nrf2-ARE.
- 总结了与ROS生产机制 (线粒体,NAD,P) H氧化酶) 相关的发现.
主要成果:
- ROS参与了关键的细胞过程,作为信号分子或转录因子调节器.
- 确定的主要ROS介导途径包括NF-κB,MAPKs,PI3K-Akt和Keap1-Nrf2-ARE.
- 各种来源有助于细胞ROS,需要有针对性的抑制策略.
结论:
- 了解ROS通路对于理解细胞反应和疾病发展至关重要.
- 发展ROS抑制剂为与氧化应激相关的疾病提供了治疗策略.
- 对ROS调节的进一步研究对于推进与氧化还原平衡相关的治疗方法至关重要.
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