复星可以通过抑制Notch/NF-κB通路来预防与年龄有关的心脏功能障碍
Le-Feng Wang1,2, Wen-Juan Li3, Xian-Yi Zhang3
1Jiangxi Province Key Laboratory of Laboratory Medicine Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang University Nanchang China.
Food science & nutrition
|February 19, 2024
概括
复星通过减少氧化应激和炎症来保护衰老的心脏. 这种天然化合物,白醇 (RSV),抑制了Notch/NF-κB通路,提供了显著的心脏保护.
科学领域:
- 心血管科学 心血管科学
- 衰老研究研究 衰老研究
- 分子生物学分子生物学
背景情况:
- 复星 (RSV) 是一种天然的多,具有潜在的抗衰老和心血管益处.
- 对RSV在衰老中的心脏保护作用的精确分子机制尚不清楚.
- 了解这些途径对于开发针对年龄相关心脏病的干预措施至关重要.
研究的目的:
- 研究RSV对与年龄有关的心脏损伤的保护作用.
- 阐明潜在的分子机制,包括特定的信号通路.
- 探索肠道功能在RSV治疗作用中的作用.
主要方法:
- 利用D-银糖诱导的老化小鼠模型.
- 评估心脏组织病理学,细胞亡,氧化应激标志物和线粒体功能.
- 分析了炎症性细胞因子水平 (IL-1β,TNF-α) 和关键蛋白质表达 (TLR4,NF-κB p65,标记1).
- 通过测量短链脂肪酸 (SCFA) 和便pH值来评估肠道功能.
主要成果:
- RSV减轻了与年龄有关的心脏损伤,减少了他的病理变化和亡.
- RSV增强了抗氧化活性和线粒体潜力,同时降低了氧化应激.
- RSV抑制了促炎性细胞因子,并抑制了诺奇/NF-κB信号通路.
- 通过增加SCFA和降低便pH,RSV改善了肠道功能.
结论:
- 通过抑制氧化应激和炎症,RSV提供了对衰老引起的损伤的心脏保护.
- 诺奇/NF-κB通路是RSV在老年小鼠中的心脏保护作用的关键目标.
- RSV的益处延伸到肠道,这表明肠心轴参与其治疗作用.
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