在炎症条件下,TiO2/PEG作为智能抗腐蚀和药物排泄平台
Sulieman Ibraheem Shelash Al-Hawary1, Ruqayah Taher Habash2, Munther Abosaooda3
1Department of Business Administration, Business School, Al al-Bayt University, Mafraq, Jordan.
Heliyon
|February 19, 2024
概括
这项研究开发了一种新的抗炎药物输送系统,用于使用响应pH的聚乙烯糖醇 (PEG) 涂层的植入物. 该系统有效释放甲 (BET),并在炎症条件下增强植入物耐腐蚀性.
科学领域:
- 生物材料工程 生物材料工程
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 植入物失败通常与炎症反应有关.
- 开发先进的涂层对于改善植入物寿命和生物相容性至关重要.
研究的目的:
- 在二氧化 (TiO2) 涂层上合成聚乙烯甘醇 (PEG) 层,用于响应pH的药物排泄平台.
- 调查贝塔梅他 (BET) 的持续释放以及开发的涂层的抗腐蚀性能.
主要方法:
- 血电解氧化 (PEO) 产生多孔的TiO2涂层.
- 真空浸泡涂层用于应用PEG-BET层.
- 在不同pH值 (5.0和7.2) 的体外药物释放研究.
- 在模拟的炎症环境中进行电化学腐蚀试验.
主要成果:
- 在30天内持续释放BET,pH值为5.0时释放81%,pH值为7.2时释放55%.
- 双重PEO/PEG-BET涂层的腐蚀电流密度 (1.75 μA cm−2) 与PEO (8.87 μA cm−2) 和赤裸的 (49.17 μA cm−2) 相比在pH值5.0时显著较低.
- 该PEG-BET层有效地封闭了毛孔,减少了腐蚀性离子透.
结论:
- PEO/PEG-BET涂层作为抗炎药物的有效pH敏感药物输送系统.
- 开发的涂层增强了在炎症条件下植入物的耐腐蚀性.
- 这种方法提供了一种有希望的策略,以减轻因炎症而导致的植入物失败.
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