医院前最佳冲击能量用于除 (POSED):一个集群随机对照可行性试验
Helen Pocock1,2, Charles D Deakin1,3, Ranjit Lall2
1South Central Ambulance NHS Foundation Trust, Talisman Way, Bicester, Oxfordshire OX26 6HR, UK.
Resuscitation plus
|February 19, 2024
概括
这项研究证明了英国救护车试验的可行性,用于在医院外心脏骤停时获得最佳的除冲击能量. 对未来的大规模试验的招聘和数据收集方法进行了评估.
科学领域:
- 紧急医疗 紧急医疗
- 心脏病学 心脏病学
- 临床试验 临床试验
背景情况:
- 医院外心脏骤停 (OHCA) 需要有效的除.
- 确定最佳冲击能量对于提高生存率至关重要.
- 在英国的救护车服务中进行大规模试验的可行性需要评估.
研究的目的:
- 评估英国救护车服务试验的可行性,以在OHCA中获得最佳的除冲击能量.
- 为了确定患者的资格和招募号码.
- 为了评估治疗的坚持和数据的完整性.
主要方法:
- 进行了一项三臂并行组集群随机控制可行性研究.
- 包括患有OHCA和可震动节律的成年患者.
- 除器被随机分配,以提供不同的冲击能量策略 (120-150-200 J,150-200-200 J,或200-200-200 J).
主要成果:
- 在2022年3月至2023年2月期间,38名符合条件的患者被随机分配.
- 招聘率为每个集群每月0.07%.
- 治疗坚持率为93%,临床/电气结局数据的完整性为86%. 在30天的生存率为8.3% (3/36).
结论:
- 在英国的救护车服务中,可以进行一个集群随机对照试验,以获得OHCA中最佳的除冲击能量.
- 确定了试验设计挑战的潜在解决方案,例如除器与车辆的分离.
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