新发代谢综合征与加速的功能下降有关,部分原因是尿酸升高:一项流行病学队列研究
Qiuyu Xu1,2, Xiaohong Fan1, Gang Chen1
1Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
新代谢综合征 (MetS) 显著加速功能衰退. 高尿酸水平,尤其是超过426μmol/L的尿酸水平,是新发性MetS患者加速下降的关键驱动因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 代谢综合征 (MetS) 的患病率正在全球范围内增加,与多器官并发症有关.
- 了解MetS状态的变化及其对功能的影响对于公共健康至关重要.
- 来自中国的区域流行病学数据可以揭示影响MetS和脏健康的可治疗因素.
研究的目的:
- 调查代谢综合征状态的变化与功能进展之间的关联.
- 确定影响因素,特别是那些容易接受治疗的因素,在MetS的背景下有助于加速衰退.
- 分析血清尿酸水平作为功能恶化的潜在标志物和贡献者的作用.
主要方法:
- 在中国农村 (2008-2014) 进行的一项以人口为基础的调查,涉及5225名参与者.
- 参与者被分为四个MetS状态组:从未,以前异常,新发作和一致.
- 多变量后勤回归,分层分析和平滑曲线拟合,以评估临床因素,MetS状态和估计的淋巴细胞过率 (eGFR) 降低之间的关系,重点是血清尿酸.
主要成果:
- 新出现的MetS与eGFR的最显著下降有关 (6.66 ± 8.21 mL/min/1.73 m2超过6年).
- 新出现的MetS增加了三角形EGFR的风险 (β=1.66,95%CI=1.09-2.23),在调整尿酸水平后,风险大幅降低 (β=0.91,95%CI=0.35-1.45).
- 血清尿酸水平高于426μmol/L与新发性MetS组的加速功能恶化有显著联系.
结论:
- 代谢综合征,特别是新发病例,与加速的功能进展有很强的相关性.
- 超尿路血症作为一个有价值的标志物,用于识别患有快速EGFR下降高风险的个体.
- 保持血清尿酸低于426μmol/L可能为新发性MetS患者提供脏益处.
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