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自决定了人类羊膜和胆管细胞中不同的细胞命运

Mary Elise L Severino^1,2, Lauren Richardson¹, Ananth Kumar Kammala¹

¹Division of Basic Science & Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Texas, USA.

Autophagy reports

|February 19, 2024

概括

氧化应激会以不同的方式影响胎儿膜细胞,影响自并导致衰老或表皮-介质细胞过渡 (EMT). 这种不同的反应可能会导致早产并发症.

科学领域:

生殖生物学生殖生物学
细胞和分子医学是细胞和分子医学.
产科和妇科的产科和妇科.

背景情况:

人类胎儿膜 (amniochorion) 维持怀孕,包括羊膜上皮细胞 (AEC) 和胆热囊细胞 (CTC).
产前膜破裂 (pPROM) 是自发早产的主要原因之一.
氧化应激 (OS) 和细胞衰老与pPROM病理生理学有关.

研究的目的:

在AECs和CTCs中研究OS诱导的p38 MAPK激活,自和上皮-介质细胞过渡 (EMT) 之间的分子相互作用.
阐明胎儿膜细胞对OS的差异性细胞反应.

主要方法:

对pPROM胎儿膜的转录分析.
在孤立的AEC和CTC中研究了OS对自和EMT的影响.
利用p38 MAPK激活,自细胞调节和衰老诱导.

主要成果:

在AEC和CTC中,OS对自产生不同的影响,导致不同的细胞命运.
在AEC中,OS诱导的p38 MAPK激活会导致自细胞积累和衰老.
在CTC中,自抑制促进SQSTM1-介导的EMT;自诱导作用有限.

结论:

AECs和CTCs对OS表现出差异性的自反应,部分由p38 MAPK介导.
除了衰老之外,羊膜细胞中的失调自也可能在机制上有助于pPROM.
胎儿膜中的OS诱导的衰老和EMT与促炎性变化有关.

关键词:

膜破裂是因为膜破裂.氧化应激是一种氧化应激.羊膜是什么意思羊膜是什么意思自自是自的过程.霍里昂霍里昂是什么意思表皮细胞-介质细胞过渡.p38 MAPKK 的时间.过早出生过早出生皮膜的早产早破皮膜的早产早破衰老是一种老化.热囊细胞的热囊细胞.

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