阻塞性睡眠呼吸暂停,夜间低氧症和视网膜微血管:社区动脉样硬化风险研究
Nathan Hoeft1, Kelsie M Full2, Jeffrey R Misialek1
1Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Sleep advances : a journal of the Sleep Research Society
|February 19, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 和低氧水平 (T90) 与更宽的视网膜静脉有关,这表明潜在的炎症和未来的心血管风险,如中风和冠心病 (CHD).
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
背景情况:
- 视网膜微血管病理 (RMP) 和阻塞性睡眠呼吸暂停 (OSA) 是已知的心血管疾病风险因素.
- 有限的研究存在于OSA和RMP之间的直接关系.
- 了解这种联系可能会为早期心血管风险检测提供见解.
研究的目的:
- 为了调查OSA,夜间低氧症 (T90) 和RMP之间的关联.
- 检查OSA严重程度和视网膜血管口径 (CRAE和CRVE) 之间的关系.
主要方法:
- 这是一项对1625名参与者进行的准横截面分析,这些参与者来自"社区动脉样硬化风险睡眠心脏健康研究".
- OSA的严重程度是通过呼吸暂停-呼吸暂停指数 (AHI) 和夜间低氧症通过T90.0来确定的.
- 视网膜摄影评估了RMP,并测量了视网膜中枢动脉等值 (CRAE) 和视网膜中枢静脉等值 (CRVE).
主要成果:
- 在严重的OSA和RMP或CRAE之间没有发现显著的关联.
- OSA的严重程度与CRVE (更宽的静脉) 呈现出正面的线性关系.
- 较高的T90 (≥5%) 与较低的T90 (<1%) 相比,与更广泛的CRVE有很强的关联.
结论:
- OSA和显著的夜间低氧症 (T90 ≥5%) 与更宽的视网膜静脉 (CRVE) 有关.
- 这些发现可能表明早期的炎症变化.
- 更宽的静脉可能意味着未来中风和冠心病 (CHD) 的风险增加.
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