较低的握力 (可能的肉症) 与胰岛素耐药性与2型糖尿病有关
Tsubasa Tajima1, Hideyoshi Kaga1, Yuki Someya2
1Department of Metabolism & Endocrinology, Juntendo University, Tokyo, 113-8421, Japan.
东亚老年人可能患有肉症和胰岛素耐药性 (IR),面临2型糖尿病 (T2DM) 的风险更高. 麻症和IR的组合在这个人群中显示出与T2DM的最强相关性.
科学领域:
- 老年学是指老年学的学科.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 在老年人中,sarcopenic肥胖会增加2型糖尿病 (T2DM) 的风险.
- 东亚人经常在没有肥胖的情况下出现胰岛素抵抗 (IR),这表明T2DM的风险概况不同.
- 在老年东亚人中,肉症,IR和T2DM之间的关系仍未得到充分研究.
研究的目的:
- 在日本老年人中调查可能的肉症,胰岛素耐药性 (IR) 和2型糖尿病 (T2DM) 之间的联系.
- 为了确定 sarcopenia 和 IR 的共存是否会放大 T2DM 的风险.
主要方法:
- 来自Bunkyo健康研究的1629名老年人 (65-84岁) 的横截面研究.
- 参与者接受了口服葡萄糖耐受性测试和手握强度测量.
- 使用手握强度和甘油三糖 (TyG) 指数分别定义了可能的肉类和IR;修改后的Poisson回归分析了T2DM风险.
主要成果:
- 在13.0%的参与者中诊断出T2DM.
- 可能的肉 (RR,1.55) 和IR (RR,2.69) 在对混因素进行调整后,独立地与T2DM相关.
- 可能的肉症和IR的共存显示出与T2DM有明显更强的关联 (RR,4.76).
结论:
- 可能的肉症和IR是日本老年人T2DM的独立风险因素.
- 可能存在的肉症和IR的联合存在,对发展T2DM的风险显著增加.
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