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基于增强多核功能SVR与PSO的乳腺癌PARP抑制剂的研究

Haohan Xue1, Ruixuan Zhang1, Xudong Yan1

  • 1University, College of Computer Science and Technology, Qingdao, China.

Frontiers in pharmacology
|February 19, 2024
PubMed
概括

研究人员开发了定量结构-活性关系模型,以抑制过度表达的PARP1,这是DNA修复中的酶. 使用三重内核函数的支持向量回归显示了设计新药分子的最强的预测能力.

关键词:
这是一种PARP抑制剂.乳腺癌 乳腺癌 乳腺癌多个内核功能多个内核功能.粒子群集优化 (PSO) 是一种量化结构与活动关系 (QSAR)支持向量的回归 (SVR)

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