时间约束的年龄相关变化,涉及听觉和静脉输入
Alexander K Malone1, Michelle E Hungerford2,3, Spencer B Smith4
1ENT and Allergy Associates of Florida, Boca Raton, Florida.
Seminars in hearing
|February 19, 2024
概括
衰老延长了大脑需要结合感官输入的时间,可能导致失衡. 这项研究发现,年长的成年人比年轻的成年人具有显著更长的前庭时结合窗口 (TBW).
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 感官整合 感官整合
背景情况:
- 保持平衡依赖于整合多感官信息,包括视觉,前体和自感信号.
- 由于生物约束,感官输入被异步处理,大脑将它们集成到一个时间绑定窗口 (TBW) 中.
- 已知衰老会延长TBW,可能增加时间不确定性,并导致与年龄相关的平衡赤字.
研究的目的:
- 为了研究衰老对前置器相关的时间结合窗口 (TBW) 的影响.
- 为了确定长时间的TBW是否会导致老年人失衡,独立于外围前庭功能.
主要方法:
- 在年轻和年长的成年人中,使用侧侧旋转和听觉刺激来比较与前庭相关的TBW.
- 参与者在地球垂直轴周围进行了0.5Hz的正弦旋转.
- 交替呈现了具有不同阶段的二声听觉刺激,以确定TBW,定义为感知同时性的时间范围 (≥75%的试验).
主要成果:
- 与年轻人 (286 ± 56 ms) 相比,老年人 (560 ± 52 ms) 的平均TBW显著更长.
- 在年轻的成年人中,TBW与前庭敏感性相关.
- 在老年人中没有观察到TBW和前庭敏感性之间的这种关系.
结论:
- 衰老延长了与前庭相关的时间结合窗口 (TBW).
- 长时间的TBW可能是导致与年龄相关的平衡障碍的关键机制.
- 这种效应似乎独立于外围前庭功能变化.
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