使用2DGC-GC-MS平台的非向代谢学方法的实用性,以区分复发性和进展性多发性硬化症
Indrani Datta1,2, Insha Zahoor3, Nasar Ata3
1Department of Public Health Sciences, Henry Ford Health, Detroit, MI, 48202, USA.
bioRxiv : the preprint server for biology
|February 19, 2024
概括
这项研究确定了与健康个体相比,多发性硬化症 (MS) 患者的独特血清代谢物概况. 这些代谢指纹可以帮助区分多发性硬化症的病程,并为诊断策略提供信息.
科学领域:
- 神经免疫学 神经免疫学
- 代谢学 代谢学 代谢学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 多发性硬化症 (MS) 是年轻人发炎性神经退行的主要原因.
- 复发性复发性 (RRMS) 和渐进性 (PPMS) 形式的MS具有不同的临床轨迹.
- 目前的诊断方法缺乏特定的生物标志物,以根据代谢概况来区分MS疾病过程.
结论:
- 改变的血清代谢物概况可以区分MS疾病过程 (RRMS,PPMS) 和健康受试者 (HS).
- 这些发现表明,有可能开发一种代谢物小组来诊断和监测像MS这样的渐进性自身免疫性疾病.
- 代谢学为识别神经退行性疾病中的新生物标志物提供了一个有前途的途径.
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