在雄性大鼠中,可卡因敏感化需要激活雌激素受体
Raissa Menéndez-Delmestre1, José L Agosto-Rivera2, Amanda J González-Segarra3
1Physiology Department, School of Medicine, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, Puerto Rico 00936-5067.
bioRxiv : the preprint server for biology
|February 19, 2024
概括
雌激醇,而不是DHT,增强了雄性大鼠对可卡因的敏感性. 这一发现突显了雌醇在可卡因诱导的神经适应和男性中易受伤害方面的关键作用.
科学领域:
- 神经内分泌学神经内分泌学
- 神经药理学神经药理学
- 药物成科学 药物成科学
背景情况:
- 淋巴腺类固醇调节可卡因使用障碍 (CUD) 并导致可卡因反应的性别差异.
- 雌激醇增强了可卡因在女性的行为效应;在男性可卡因敏感化中的作用是已知的,但其机制尚不清楚.
研究的目的:
- 为了研究二测试 (DHT) 和雌激素在调节雄性大鼠中可卡因诱导的敏感性方面的作用.
- 阐明非可芳香的雄激素与雌激素在男性可卡因神经适应中的特定贡献.
主要方法:
- 淋巴切除 (GDX) 的雄性大鼠接受了雌激醇或DHT的治疗.
- 完整的雄性大鼠接受了抗雌激素ICI 182,780.
- 所有组都接受了重复的可卡因管理,以评估敏感性.
主要成果:
- 在GDX雄性大鼠中,雌激醇治疗恢复了可卡因敏感性.
- 在GDX雄性大鼠中,DHT治疗没有诱导可卡因敏感性.
- 与ICI 182,780对抗雌激素阻断了完整的雄性大鼠中的可卡因敏感性.
结论:
- 雌激醇,而不是DHT,对雄性大鼠中可卡因诱导的敏感性至关重要.
- 这项研究涉及雌激醇调解可卡因诱导的神经可塑性和神经适应性在雄性动物大脑.
- 研究结果表明,雌醇在男性易受可卡因使用障碍的影响中起着关键作用.
关键词:
在 ICI 182 780 中.敏感化 敏感化色素是一种色素.抗雌激素是一种抗雌激素.这是可卡因,可卡因.二二二二二二二二二二二二二二雌二醇是雌二醇的一种药物.在faslodex中使用.一个男的男人,一个男的男人.测试剂 测试剂 测试剂 测试剂更多相关视频
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