在老鼠中部前额叶皮层中的围神经网络改变了海马前额叶振荡,并重塑了可卡因自我管理的记忆
bioRxiv : the preprint server for biology
|February 19, 2024
概括
在中枢前额叶皮层 (mPFC) 中去除周神经网络 (PNNs) 可以防止可卡因记忆形成并破坏其再巩固,从而有可能减少可卡因使用障碍的复发.
科学领域:
- 神经科学是一个神经科学.
- 分子和细胞神经科学
- 成研究 研究成研究
背景情况:
- 中间前额皮质 (mPFC) 对于可卡因复发至关重要,其功能由表达帕瓦胺 (PV) 的内部神经元调节,这些内部神经元被包裹在周围神经网络 (PNN) 中.
- PNN是专门的细胞外矩阵结构,调节神经元可塑性和电路功能.
结论:
- 删除PNN可以防止获得可卡因自我管理记忆.
- 破坏PNN,特别是在新的记忆重新激活期间,有效地损害了可卡因记忆的再巩固.
- 在PNN移除后降低dHIP-mPFC合可能代表破坏可卡因记忆再巩固和降低复发风险的生物标志物.
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