基因预测的铁状况与心血管疾病风险之间的关联:孟德尔的随机化研究
Alexa Barad1, Andrew G Clark2,3, Kimberly O O'Brien1
1Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA.
medRxiv : the preprint server for health sciences
|February 19, 2024
概括
较高的铁状况增加了心血管血栓性中风风险,独立于其他心血管疾病风险因素. 扩张性血压部分调解了这种铁中风相关性,这表明铁是一种可修改的风险因素.
科学领域:
- 心血管疾病遗传学 心血管疾病遗传学
- 铁代谢和心血管健康
- 门德尔的随机化研究.
背景情况:
- 门德尔随机化 (MR) 研究表明,铁 (Fe) 状态影响心血管疾病 (CVD) 风险.
- 工具变量 (IVs) 对心血管疾病风险因素的乐质变量影响的潜在混需要调查.
- 这项研究调查了Fe状态对心血管疾病风险的影响,控制了已确定的心血管疾病风险因素.
研究的目的:
- 调查Fe状态对心血管疾病风险的因果关系.
- 评估常见心血管疾病风险因素对Fe状况与心血管疾病之间的关联的影响.
- 为了确定Fe状态是否是特定心血管事件的独立风险因素.
主要方法:
- 使用了两样单变量 (UV) 和多变量 (MV) 门德尔随机化 (MR).
- 从事Fe生物标志物IVs (TIBC,TSAT,SI,费里丁) 来自欧洲GWAS的元分析.
- 使用MEGASTROKE和CARDIOGRAMplusC4D联盟的数据评估了与心血管疾病结局 (缺血性中风亚型,冠心病) 的关联.
- 在MVMR分析中调整了六个心血管疾病风险因素,以评估混和调解.
主要成果:
- 更高的基因预测Fe状态与心血管栓塞性中风 (CES) 的风险增加有关.
- 在对心血管疾病风险因素进行调整后,这些对CES风险的不利影响仍然存在.
- 透气血压被确定为调解剂,解释了7.1-8.8%的Fe状态-CES关联.
- 最初建议Fe状态对大动脉中风和冠心病的保护作用在MVMR分析中被取消.
结论:
- 铁水平升高与心血管血栓性中风风险更高有关,这与常见的心血管疾病风险因素无关.
- 扩张性血压是铁状况和CES之间的途径中确定的调解器.
- 铁状况成为心血管栓塞性中风的潜在可改变的风险因素.
相关概念视频
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
Human Genetics
569
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
569
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
Study Designs in Epidemiology
217
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
217


