事故心力衰竭后认知功能的发展轨迹
Supriya Shore1, Hanyu Li1, Min Zhang1
1University of Michigan, Ann Arbor, MI, USA.
medRxiv : the preprint server for health sciences
|February 19, 2024
概括
新的心力衰竭 (HF) 诊断与全球认知和执行功能的立即下降有关. 与没有这种情况的人相比,HF患者的认知衰退加速.
科学领域:
- 心血管医学 心血管医学
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 发生性心力衰竭 (HF) 对认知功能的影响仍然不完全理解.
- 现有的研究尚未完全解释HF前的认知轨迹和已确定的认知决定因素.
- 这项研究解决了需要澄清新的HF诊断后认知变化的大小.
研究的目的:
- 评估发生心力衰竭 (HF) 和随后的认知功能变化之间的关联.
- 量化HF诊断时的认知变化以及事件发生后的几年.
- 为了控制HF前的认知轨迹和影响认知的已知因素.
主要方法:
- 一个综合的队列研究,利用来自美国六个大型基于人口的队列 (1971-2019) 的数据.
- 纳入标准:没有先前的HF,中风或痴呆症的成年人.
- 使用线性混合效应模型来估计全球认知,执行功能和记忆的变化,并根据HF前的认知状态和参与者特征进行调整.
主要成果:
- 发作性心力衰竭 (HF) 与诊断时全球认知 (-1.08 分) 和执行功能 (-0.65 分) 的急性下降有关.
- 与没有HF的个体相比,发生HF的个体在诊断后表现出更快的认知衰退:全球认知 (-0.15分/年) 和执行功能 (-0.16分/年).
- 这些关联在老年人,女性和白人中更为明显;记忆功能没有受到显著影响.
结论:
- 发生性心力衰竭 (HF) 与全球认知和执行功能的急性下降有显著的关联.
- 在HF诊断后,与HF前的轨迹相比,个体在全球认知和执行功能方面经历了加速下降.
- 这些发现突显了心力衰竭对认知的影响,强调了综合护理方法的必要性.
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