在中年成人中,压力引起的大脑活动,心血管反应能力和亚临床动脉样硬化
Javier Rasero1,2, Timothy D Verstynen1, Caitlin M DuPont3
1Department of Psychology, Carnegie Mellon University, PA.
medRxiv : the preprint server for health sciences
|February 19, 2024
概括
心理压力会影响大脑活动和临床前动脉样硬化. 在压力期间的系统性血压 (SBP) 反应调解了这种联系,将大脑功能与血管疾病的早期迹象联系起来.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 心理生理学 心理生理学
背景情况:
- 心理压力因素与临床前动脉样硬化和大脑活动有关.
- 以前的研究尚未确定心血管应激反应是否与同一个人中的大脑活动和动脉样硬化有关.
- 这项研究研究了心血管应激反应的调解作用.
研究的目的:
- 为了确定压力引起的缩血压 (SBP) 反应是否调解大脑活动和临床前动脉样硬化之间的关联.
- 利用交叉验证和预测建模进行可靠的分析.
- 为了检查同一个个体内的这些关系.
主要方法:
- 来自两个群体的624名中年成年人参加了这项研究.
- 在信息冲突任务期间收集了功能磁共振成像 (fMRI) 和并发的SBP测量.
- 用超声波测量动脉内心介质厚度 (CA-IMT).
- 采用了一个调解框架,采用交叉验证和处罚的主要组件回归.
- 使用引导和灵敏度分析来验证发现.
主要成果:
- 血液动力学大脑反应显示了与CA-IMT的概括关联.
- 这种关联是由总体SBP反应性介导的.
- 涉及的关键大脑区域包括腹中前额叶皮质,前带皮质,胰岛和杏仁体.
- 在敏感性分析中,调查结果保持稳健.
结论:
- 压力引起的大脑活动与临床前动脉样硬化有关.
- 在压力期间心血管反应的个体差异解释了这一联系.
- 这些发现突出了影响血管健康的心理生理途径.
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