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患者报告的肺输出的结果:一个系统性审查
Eleanor K Mishra1,2, Andrew Stanton3
1Respiratory Medicine, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, GBR.
Cureus
|February 19, 2024
概括
患者报告的结果测量 (PROMs) 在肺溢试验中显示呼吸困难的改善. 然而,只有视觉模拟呼吸障碍 (VASD) 的视觉模拟尺度得到了最小临床重要差异 (MCID) 的验证.
科学领域:
- 肺部医学 肺部医学
- 临床试验方法论 临床试验方法论
- 患者报告的结果
背景情况:
- 胸腔溢出严重影响患者的生活质量,导致呼吸困难和活动减少.
- 患者报告的结果指标 (PROMs) 对于评估流的临床试验中的干预措施至关重要.
- 评估PROM的有效性和响应性对于准确的结果测量至关重要.
研究的目的:
- 系统地审查在膜溢出排水临床试验中使用的PROM.
- 确定评估的变量,对干预措施的响应能力和PROM的验证状态.
- 为了确定这个患者组中PROMs是否已经确定了临床重要差异最小值 (MCID).
主要方法:
- 通过Medline,EMBASE,Emcare和CINAHL数据库识别的临床试验的系统审查.
- 从29个已识别的临床试验中提取数据,这些临床试验使用PROM用于膜溢液排水.
- 对16种不同的PROM进行了分析,分析了它们的使用,评估变量,响应能力和验证.
主要成果:
- 确定了16种不同的PROM,其中最常见的是单维呼吸困难测量.
- 呼吸障碍视觉模拟量表 (VASD) 显示出响应性,并且是唯一一个通过定义的MCID验证的PROM.
- 多维PROM显示出不一致的响应,没有一个PROM捕获了所有关键结果.
结论:
- 多种PROMs被用于肺溢临床试验,但没有一个全面地解决了所有结果.
- 单维性呼吸困难测量,特别是VASD,对肺部液体排水有反应.
- 对于经过验证的,响应性强的PROMs存在着极大的需求,这些PROM可以捕捉到肺部溢出患者的关键结果.
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