运动对西斯普拉丁诱导的认知和扩散障碍的反作用
Maha Elbeltagy1,2, Ramzi A Al-Horani3, Tala S Alsharaeh4
1Department of Anatomy and Histology, Faculty of Medicine, The University of Jordan, Amman, JOR.
Cureus
|February 19, 2024
概括
身体炼可能会抵消西斯丁的作用.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 运动生理学 运动生理学
背景情况:
- 西斯普拉丁化疗通过影响神经发生和增加氧化应激会导致认知障碍.
- 身体活动被探索为化学疗法诱导的副作用的对策.
- 了解运动对西斯普拉丁神经毒性的影响,对于支持性癌症治疗至关重要.
研究的目的:
- 在小鼠模型中研究中等强度体育炼对西斯普拉丁诱导的认知障碍的影响.
- 为了评估运动对海马增殖和氧化应激标志物的影响,西斯普拉丁治疗后.
- 评估运动在减轻西斯普拉丁诱导的体重减轻中的作用.
主要方法:
- 成年雄性小鼠被分为对照组,西斯治疗组和运动/西斯治疗组.
- 西斯普拉丁在一个月的时间内被给予;运动组同时进行中等强度的运动.
- 评估了空间记忆 (新型物体识别任务),海马扩散 (Ki-67 IHC) 和氧化应激 (GPx IHC).
主要成果:
- 西斯普拉丁治疗显著损害了空间记忆,并减少了海马扩散.
- 与西斯普拉丁一起炼减轻了认知缺陷,并保留了海马的扩散.
- 西斯普拉丁增加了氧化应激,导致体重减轻;运动减轻了这些影响.
结论:
- 西斯普拉丁化疗诱导了小鼠的认知衰退,海马功能障碍和体重减轻.
- 中等强度的运动可以改善西斯普拉丁诱导的神经毒性和认知障碍.
- 身体活动可以作为一种有价值的补充策略,用于接受西斯治疗的癌症患者.
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