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在前列腺癌的诊断工作中Proclarix的评估

Basil Kaufmann^1,2, Sharon Fischer¹, Alcibiade Athanasiou³

¹Department of Urology University Hospital Zurich Zurich Switzerland.

|February 19, 2024

概括

普罗克拉里克斯对检测临床显著的前列腺癌 (csPCa) 具有很高的敏感性,并且普罗克拉里克斯的密度可以帮助避免PI-RADS 3病变的男性中不必要的活检.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
医疗成像医学成像

背景情况:

多参数磁共振成像 (mpMRI) 是前列腺癌 (PCa) 诊断的标准.
mpMRI病变可能是不确定的,导致错误的阳性活检.

研究的目的:

评估Proclarix生物标记测试,以检测相关的PCa.
评估Proclarix在活检前和PI-RADS 3病变的男性的诊断价值.

主要方法:

预期招募男性进行前列腺活检.
评估Proclarix对临床显著的PCa (csPCa) 检测和与mpMRI的关联.
普罗克拉里克斯密度和PSA密度 (PSAD) 的比较.

主要成果:

普罗克拉里克斯对csPCa.有很高的敏感性 (94%).
普罗克拉里克斯密度实现了csPCa检测的最高AUC (0.77).
在PI-RADS 3病变中,Proclarix密度识别了所有csPCa,性能优于PSAD,并可能避免41%的活检.

结论:

普罗克拉里克斯对csPCa检测具有很高的灵敏度.
对于PI-RADS 3病变来说,Proclarix密度很有价值,可以安全地避免活检,而不会错过csPCa.

关键词:

普罗克拉里克斯 (Proclarix) 是一个著名的传教士.生物标志物生物标志物活组织活检卡瑟普辛D,CTSD的使用情况前列腺癌是前列腺癌.血栓素1,THBS1 的一个.

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