康贝塞普特的静脉内射注射用于糖尿病黄斑胀,并发症为糖尿病病
Yuan-Zhang Zhu1, Zhi-Zhi Dou1, Wen-Ying Wang1
1Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China.
International journal of ophthalmology
|February 19, 2024
概括
康伯塞普有效治疗糖尿病黄斑 (DME) 有或没有糖尿病病 (DN),改善视力和减少视网膜胀. 然而,没有DN的患者表现得比DN患者更好.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 糖尿病病 (DN) 是糖尿病的常见并发症,可以影响整体健康结果.
研究的目的:
- 评估conbercept在DME患者的治疗疗效,特别是那些也被诊断为DN的患者.
- 为了比较DME患者与没有同时存在的DN之间的治疗结果.
主要方法:
- 54名DME患者的回顾性研究,分为25只眼睛和没有 (29只眼睛) DN的组.
- 通过OCT评估最佳校正的视敏度 (BCVA),中央黄斑厚度 (CMT),视网膜高反射焦点 (HF),以及相关的临床/实验室参数.
- 监控圆形区域 (EZ) 和外部限制膜 (ELM) 的完整性.
主要成果:
- 与没有DN的DME患者相比,患有DME和DN的患者表现出更差的EZ和ELM完整性,更差的BCVA和更高的CMT和HF.
- 在两组中,Conbercept治疗导致BCVA,CMT和HF的显著改善.
- 6个月后,需要注射conbercept的数量在DN组的DME (4.84) 和没有DN组的DME (3.79) 中较高.
结论:
- 康伯塞普特对DME表现出显著的短期治疗效果,改善了BCVA,CMT和HF.
- 在没有并发性DN的DME患者中,治疗疗效更为明显.
- DN的存在对DME的整体治疗结果产生了负面影响.
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