在多发性硬化症中表达eomesodermin的CD4+Th细胞和与怀孕的关联.
Simon Faissner1, Marielena Bongert2, Paulina Trendelenburg2
1Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, Bochum 44791, Germany.
Therapeutic advances in neurological disorders
|February 19, 2024
概括
在多发性硬化症 (MS) 中的怀孕会改变免疫细胞,Eomesodermin阳性T辅助细胞 (Eomes+Th) 与产后残疾相关. 这些发现表明,在怀孕晚期的发作性炎症状态有助于产后MS进展.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 生殖医学 生殖医学
背景情况:
- 多发性硬化症 (MS) 复发率在怀孕期间下降,但在分娩后增加.
- 欧梅索德明阳性T辅助细胞 (Eomes+Th) 与MS神经炎症和疾病进展有关.
- 在怀孕和产后MS中Eomes+Th细胞的作用尚未完全理解.
研究的目的:
- 为了研究MS的孕妇和产后患者的免疫细胞变化.
- 确定Eomes+Th细胞在怀孕期间和分娩后的MS疾病活动中的病理生理学作用.
主要方法:
- 对81名孕妇,27名产后患者和26名对照女性多发性硬化症患者的免疫细胞种群的分析.
- 利用流细胞计量来分析免疫细胞的变化.
- 采集的临床数据和使用扩展残疾状态量表 (EDSS) 评估残疾.
主要成果:
- 与非孕妇对照组相比,产后多发性硬化症患者的CD3+CD8+细胞毒性T细胞增加和B细胞减少.
- 自然杀手 (NK) 细胞在第一季度与第三季度相比升高.
- 在怀孕晚期,Eomes+Th细胞与调节性T细胞减少和B细胞增加相关,并且与产后残疾 (EDSS) 有很强的相关性.
结论:
- 在MS中怀孕与显著的免疫学转移有关.
- Eomes+Th细胞在怀孕期间的免疫变化中发挥作用,特别是在第二和第三个三个月.
- 在怀孕晚期形成的炎症环境可能会导致MS产后残疾累积.
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