作为糖尿病发病率预测工具的ZJU指数:基于人口的队列研究的见解
Chenjiao Wu1, Yi Hao Loh2, Hangkai Huang3
1Department of Nursing, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|February 19, 2024
概括
脂肪肝疾病的预测指数ZJU指数与亚洲人群糖尿病发病风险增加有关. 较高的ZJU指数得分与发生糖尿病的可能性更高相关.
科学领域:
- 代谢健康 代谢健康
- 流行病学 流行病学
- 糖尿病研究研究 糖尿病研究
背景情况:
- 在中国人群中,ZJU指数在预测非酒精性脂肪性肝病方面表现有前途.
- 它与亚洲更广泛的人群糖尿病风险的关联仍未得到充分研究.
研究的目的:
- 调查ZJU指数与亚洲人群中发生糖尿病发病风险之间的关联.
- 确定ZJU指数是否是该人口群体中糖尿病的重要预测指标.
主要方法:
- 利用了NAGALA研究 (1994-2015年) 的数据,其中包括15,464名参与者.
- 采用考克斯的比例危险回归来分析ZJU指数四分位数和发生糖尿病之间的关系.
- 该ZJU指数包括BMI,禁食葡萄糖,甘油三和ALT/AST水平,并对女性进行调整.
主要成果:
- 在93,350个人年中,共记录了373例糖尿病病例.
- 增加的ZJU指数得分与较高的糖尿病发病率显著相关 (P < 0.001).
- ZJU指数的最高四分位数显示糖尿病风险增加了2.5倍 (HR=2.519).
- 亚组分析显示,在年轻人 (<40岁),女性,正常BMI (<25 kg/m2) 和不太活跃的个体中存在显著的关联.
结论:
- ZJU指数与亚洲总人口中发生的糖尿病发生率有关.
- 该指数可以作为一种有价值的工具,用于识别患糖尿病风险较高的个体.
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