一项基于机构的跨部门观察性病因学研究,将获得的手掌叶角皮皮肤病患者的临床病理发现联系起来
Indrayudh Sen1, Dhiman Tarafdar1, Somenath Sarkar1
1From the Department of Dermatology, Bankura Sammilani Medical College, Bankura, India.
Indian journal of dermatology
|February 19, 2024
概括
获得的棕植物角质皮肤病 (PPK) 诊断往往显示出不良的临床-组织学相关性,高角质皮肤湿疹经常被误诊为牛皮. 皮肤活检对于准确的PPK诊断至关重要.
科学领域:
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
背景情况:
- 棕植物性角皮肤病 (PPK) 包含各种遗传和获得的疾病,导致手掌和脚的过度表皮加厚.
- 了解PPK病因和临床概况是有效管理和结果预测的关键.
研究的目的:
- 为了确定各种皮肤病的患病率,作为获得的棕植物性角皮肤病.
- 描述这些条件的临床-组织学相关性.
主要方法:
- 一项涉及67名获得PPK的患者的横截面研究.
- 临床评估,人口统计数据收集,实验室检查和三名盲人专家的组织病理学检查.
- 使用专用软件进行统计分析.
主要成果:
- 牛皮在临床上被诊断为58.2%,在组织学上为10.4%;平 (LP) 在临床上为23.9%,在组织学上为13.4%;Pityriasis rubra pilaris (PRP) 在临床上为11.9%,在组织学上为10.4%;超皮湿疹 (HKE) 在临床上为6%和在组织学上为64.2%.
- 观察到较差的评价者间一致性 (Kappa = 0.148).
- 临床病理相关性在牛皮的17.9%,LP的56.2%,PRP的87.5%是可接受的. 在65.1%的病例中,HKE被误诊为牛皮.
结论:
- 叠加的临床特征在高角质手掌和脚病变需要皮肤活检进行准确的诊断.
- 组织病理学检查对于区分HKE和牛皮等疾病至关重要.
相关概念视频
01:11Papillary Dermis
5.9K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.9K
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
773
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
773