在Staphylococcus Aureus殖民和儿科无皮炎之间的协会:一个系统的审查和元分析
Phoomphut Sangaphunchai1, Chawan Kritsanaviparkporn1, Arucha Treesirichod1
1From the Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Rangsit-Nakhonnayok Road, Ongkharak, Nakhonnayok, Thailand.
Indian journal of dermatology
|February 19, 2024
概括
与健康个体相比,患有亚形性皮肤炎 (AD) 的儿童表现出明显更高的金黄色葡萄球菌皮肤和鼻腔殖民率. 这突显了小儿阿尔茨海默病恶化的关键关联.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 儿科 儿科 儿科
背景情况:
- 亚托邦性皮肤炎 (AD) 是一种慢性炎症性皮肤疾病,在儿童早期流行.
- 阿尔茨海默病的急性恶化通常与金黄色葡萄球菌殖民有关.
研究的目的:
- 为了调查Staphylococcus aureus (S. aureus) 在皮肤和鼻腔通道上的殖民之间的关系,在儿童身上有无形性皮肤炎.
- 与对照组相比,量化小儿阿兹海默症患者中S. aureus殖民的流行率和几率.
主要方法:
- 进行了系统性审查和元分析.
- 包括的研究比较了儿科亚型皮肤炎患者 (≤18岁) 与非患病的对照.
- 采用随机效应模型来确定S. aureus殖民的综合流行率和几率比率.
主要成果:
- 分析包括26项研究中的2670例病例和1224例对照.
- 在疹皮肤上 (OR: 10.55) 和鼻腔 (OR: 2.38) 上的亚托皮炎患者中,S. aureus的殖民性显著更高.
- 黄金色杆菌殖民的总流行率在湿疹皮肤上为55.0%,在非损伤皮肤上为23.3%,在鼻腔中为56.3%. 甲素耐药黄金色杆菌 (MRSA) 的发病率在鼻中为11.6%,在湿疹皮肤上为8.5%.
结论:
- 与未患病的同行相比,被诊断患有亚托邦性皮炎的儿童对S. aureus在皮肤和鼻腔中的定居更容易受到感染.
- 这些发现强调了S. aureus在儿科亚托邦性皮肤炎的病理生理学中的重要作用.
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