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发酵混合谷物改善慢性压力诱导的类似抑郁的行为和记忆缺陷

Jae Gwang Song¹, Bomi Lee¹, Do Eon Kim¹

¹Department of Bio-integrated Science and Technology, College of Life Sciences, Sejong University, Seoul, 05006 Republic of Korea.

Food science and biotechnology

|February 19, 2024

概括

发酵混合谷物 (FG) 可以缓解压力诱导的肠道炎症和大脑功能障碍. 这项研究表明,在暴露于慢性压力的小鼠中,FG可以减少焦虑,抑郁和记忆丧失.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
胃肠病学胃肠病学

背景情况:

发酵混合谷物 (FG) 具有抗癌,抗氧化和抗炎性质.
无法预测的慢性轻度压力 (UCMS) 可以诱导肠道炎症,大脑功能障碍和行为变化.
研究FG在与压力相关的疾病中的治疗潜力至关重要.

研究的目的:

评估FG在减轻UCMS诱导的肠道炎症,大脑功能障碍和小鼠焦虑/抑郁类行为方面的疗效.
评估FG在慢性压力条件下对认知功能和大脑中的特定分子标记物的影响.
确定FG对UCMS引起的肠损伤的保护作用.

主要方法:

给小鼠服用混合谷物或FG,持续3周.
在给药后,小鼠接受了为期4周的UCMS协议.
进行了行为测试,认知评估,以及对大脑mRNA水平 (5-HTR1A,IL-6) 和肠道损伤的分析.

主要成果:

施用FG显著改善了压力诱导的焦虑/绝望类行为.
FG预防了UCMS诱导的记忆障碍,并恢复了大脑中5-HTR1A和IL-6的正常mRNA水平.
与对照组相比,FG的使用抑制了压力小鼠的肠道损伤.

结论:

发酵混合谷物显示出在减轻压力诱导的肠道炎症方面具有显著的潜力.
FG有效地减轻UCMS诱导的大脑功能障碍,包括认知障碍和行为改变.
黄作为一个有前途的治疗剂,用于管理与压力相关的胃肠道和神经系统疾病.

关键词:

慢性轻度压力慢性轻度压力类似抑郁症的行为发酵的谷物发酵的谷物记忆障碍记忆障碍记忆障碍

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