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高VTA1表达是肺腺癌的不良预后因素

Xingang Sun¹, Ruixin Wu², Xinjun Guan³

¹Department of Oncology, Huzhou Hospital of Traditional Chinese Medicine, Zhejiang University of Traditional Chinese Medicine, Huzhou 313000, China. dfr34568@163.com.

Cellular and molecular biology (Noisy-le-Grand, France)

|February 19, 2024

概括

在非小细胞肺癌类型的肺腺癌 (LUAD) 中,VTA1的表达很高. 高VTA1表达表明预后不佳,并作为LUAD患者不良结果的潜在生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

肺腺癌 (LUAD) 是一种流行的非小细胞肺癌亚型.
确定可靠的生物标志物用于LUAD进展是一个关键的临床挑战.
尽管与其他癌症有关,但VTA1在LUAD中的作用尚未得到充分研究.

研究的目的:

为了研究VTA1在LUAD中的表达模式.
分析VTA1表达和LUAD患者的临床结果之间的相关性.
探索与LUAD中VTA1相关的分子机制和途径.

主要方法:

利用了来自癌症基因组图谱 (TCGA) 和基因型-组织表达 (GTEx) 项目的RNA测序数据.
进行了差异基因表达 (DEG) 分析,基因本体学 (GO) /基因和基因组的京都百科全书 (KEGG) 路径分析,基因组丰富分析 (GSEA) 和蛋白质-蛋白质相互作用 (PPI) 网络分析.
使用卡普兰-梅尔生存分析,考克斯回归和预后诺莫格拉姆模型评估临床意义.

主要成果:

与正常样本相比,LUAD组织中的VTA1显著上调.
高VTA1表达与先进的T,N,M阶段,病理阶段和残留瘤状态相关.
高VTA1表达是LUAD患者生存率低下的独立预后因素,与4232个差异表达基因相关.

结论:

过度表达VTA1是肺腺癌不良预后的潜在生物标志物.
已识别的DEG和途径为LUAD瘤发生和进展提供了洞察力.
对VTA1作用的进一步研究可能会导致针对LUAD的新型治疗策略.

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