随着时间的推移,血压表型中的性别差异 - - HELIUS研究
Esther M C Vriend1,2, Thomas A Bouwmeester1, Oscar H Franco3
1Amsterdam UMC, University of Amsterdam, Department of Internal Medicine, Section Vascular Medicine, Amsterdam Cardiovascular Sciences.
Journal of hypertension
|February 19, 2024
概括
患有高血压表型的年轻人面临着不同的风险. 与男性相比,女性,特别是那些患有隔离性透气高血压的人,随着时间的推移患高血压的风险更高,这强调了需要警血压监测的必要性.
科学领域:
- 心血管健康 心血管健康
- 高血压的表型化 高血压的表型化
- 基于性别的风险评估
背景情况:
- 高血压的分类依据静缩和静缩血压 (BP) 不同.
- 血压的表型差异对年轻男性和女性具有不同的预后值.
- 关于BP表型的性别特异纵向变化存在有限的数据.
研究的目的:
- 研究45岁以下成年人高血压表型自然进展的性别差异.
- 为了比较随着时间的推移在男性和女性不同的基线BP表型中发展高血压的风险.
主要方法:
- 利用了来自多民族,基于人口的HELIUS研究的数据.
- 分层参与者 (年龄<45岁) 分为正常血压,孤立的静脉缩性高血压 (ISH),孤立的透气性高血压 (IDH) 和静脉缩性透气性高血压 (SDH) 组.
- 在随访时使用调整为共变量的后勤回归来确定高血压风险.
主要成果:
- 包括4103名参与者,平均随访时间为6.2年.
- 所有高血压表型都显示,与正常血压相比,随访时患高血压的几率增加.
- 与男性相比,女性在所有表型中始终表现出更高的患高血压的几率比率,尤其是在IDH组中.
结论:
- 与男性相比,女性,特别是那些患有隔离性腹筋高血压的女性,面临着随着时间的推移发展高血压的显著更高风险.
- 这些发现凸显了年轻人密切监测血压的必要性,特别强调女性.
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