Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Decision Making: P-value Method01:09

Decision Making: P-value Method

5.3K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can...
5.3K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

126
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
126
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

3.1K
Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
3.1K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

73
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
73
Actuarial Approach01:20

Actuarial Approach

78
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
78

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Endovascular-first revascularization is as safe and efficacious as open-first revascularization for acute limb ischemia.

Journal of vascular surgery·2026
Same author

Thirty-day outcomes following transcarotid artery revascularization with integrated embolic protection: The PERFORMANCE III study.

Journal of vascular surgery·2026
Same author

Extending the Observational Medical Outcomes Partnership Common Data Model to Support Observational Peripheral Vascular Disease Research.

The Journal of surgical research·2026
Same author

Open surgery appears to be the preferred treatment in patients with nutcracker syndrome: A vascular low frequency disease consortium analysis.

Journal of vascular surgery. Venous and lymphatic disorders·2026
Same author

Benefits of Multi-Disciplinary Limb Preservation Teams.

Clinics in podiatric medicine and surgery·2026
Same author

Implicit Bias and Recognition of Biases Among Vascular Surgeons.

The Journal of surgical research·2026

相关实验视频

Updated: Jul 2, 2025

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
04:09

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Published on: October 10, 2018

8.2K

个性化治疗规则通过价值函数替代品的表征.

Nikki L B Freeman1, Sydney E Browder2, Katharine L McGinigle3

  • 1Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States.

Biometrics
|February 19, 2024
PubMed
概括

精准医学策略可以通过贝叶斯优化来改进,以学习最佳的个性化治疗规则,特别是在外围动脉疾病伤口管理与部分遵守等环境中. 这种方法也是临床翻译的治疗规则类的特征.

关键词:
斯过程是高斯过程.个性化治疗规则是个性化治疗的规则.精准医学是一门精准医学.代孕模型的代孕模型翻译科学是翻译科学.

更多相关视频

Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods
13:04

Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods

Published on: September 19, 2012

12.1K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.5K

相关实验视频

Last Updated: Jul 2, 2025

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
04:09

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Published on: October 10, 2018

8.2K
Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods
13:04

Measuring the Subjective Value of Risky and Ambiguous Options using Experimental Economics and Functional MRI Methods

Published on: September 19, 2012

12.1K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.5K

科学领域:

  • 生物医学信息学 生物医学信息学
  • 临床研究 临床研究
  • 统计学学习 统计学学习

背景情况:

  • 精准医学旨在通过定制治疗来改善医疗保健,但统计策略和现实世界实施之间存在差距.
  • 实施精准医学的挑战包括特定的环境因素,如患者对治疗计划的部分遵守.
  • 周围动脉疾病 (PAD) 伤口管理为应对这些实施挑战提供了相关的临床背景.

研究的目的:

  • 证明使用贝叶斯优化与高斯过程替代品来学习最佳个性化治疗规则 (ITR) 的可行性.
  • 为了解决患有外围动脉疾病的患者在伤口治疗中部分遵守的具体挑战.
  • 将应用范围扩展到不仅仅是学习单一的最佳ITR,还包括ITR类和其临床翻译的特征.

主要方法:

  • 采用贝叶斯优化,利用高斯过程替代值函数.
  • 专注于周围动脉疾病患者的临床情景,部分遵守伤口管理协议.
  • 开发了用于描述ITR类的方法,而不仅仅是单一的最佳规则.

主要成果:

  • 展示了贝叶斯优化在特定临床环境中学习最佳ITR的可行性.
  • 证明有能力描述不同类别的ITR.
  • 提供了关于将这些发现转化为实际临床应用的见解.

结论:

  • 贝叶斯优化为开发有效的个性化治疗规则提供了一种可行的方法,即使部分遵守.
  • 鉴定ITR类的特征增强了精准医学策略的实际实用性和适应性.
  • 提出的方法有助于将先进的统计学学习转化为现实世界的临床决策,以改善患者的治疗结果.