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Updated: Jul 2, 2025

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在血管氧化还原信号中和NRF2之间的相互作用
Fan Yang1, Matthew J Smith1, Richard C M Siow1
1School of Cardiovascular and Metabolic Medicine and Sciences, King's British Heart Foundation Centre of Research Excellence, Faculty of Life Sciences and Medicine, King's College London, 150 Stamford Street, London SE1 9NH, U.K.
Biochemical Society transactions
|February 19, 2024
概括
(Zn) 对血管健康至关重要,影响内皮功能和抗氧化剂反应. 本综述探讨了,活性氧物种和血管细胞中的NRF2通路之间的复杂关系.
科学领域:
- 心血管生物学 心血管生物学
- 细胞还氧化剂恒常状态 细胞还氧化剂恒常状态
- 微量金属的新陈代谢
背景情况:
- (Zn2+) 对于血管健康至关重要,它调节内皮氧化合成酶,并防止氧化应激.
- 缺乏和过量都会对内皮细胞产生负面影响,导致炎症或亡.
- 核因子-E2相关因子2 (NRF2) 是一个关键的转录因子,调节细胞对氧化应激反应.
研究的目的:
- 审查反应性氧物种,和血管细胞中的NRF2信号之间的复杂相互作用.
- 突出作为生物标志物和潜在治疗剂在与氧化相关的血管疾病中的作用.
- 阐明如何影响NRF2激活及其下游目标.
主要方法:
- 文献综述侧重于研究,氧化应激和血管环境中的NRF2.
- 对影响NRF2调节者的分子机制的分析 (KEAP1,GSK3β,BACH1).
- 检查对参与NRF2激活的信号通路 (MAPK,PI3K,PKC) 的影响.
主要成果:
- 通过与其调节器相互作用并影响酸化信号通路来调节NRF2活性.
- 反过来,NRF2向蛋白质可以通过载体 (ZnTs,ZIPs) 和金属氨酸调节细胞平衡.
- 这种交叉对话对氧化应激和缺氧/氧化复原下血管细胞中抗氧化剂防御机制至关重要.
结论:
- 在血管细胞适应氧化应激的过程中起到多方面的作用,主要通过NRF2信号传递进行介导.
- 了解-NRF2轴为血管疾病的新诊断和治疗策略提供了潜力.
- 对和NRF2的动态调节进行进一步的研究对于临床应用是有必要的.
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