甲状腺激素替代疗法对为良性多结肠进行全切或全甲状腺切除术的患者的死亡率的影响
Erik Nordenström1, Jonas Ranstam1, Anders Bergenfelz1
1Department of Clinical Sciences-Lund, Lund University, Sweden.
BJS open
|February 19, 2024
概括
针对良性结节的甲状腺切除术后的甲状腺激素替代疗法可能会降低死亡风险. 手术后的激素治疗与良性甲状腺疾病患者的更好的结果有关.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 公共卫生 公共卫生
背景情况:
- 良性非毒性结节性喉的甲状腺手术是一种常见的内分泌手术程序.
- 甲状腺激素替代疗法 (THRT) 在良性甲状腺疾病手术后对死亡率和发病率的影响尚未得到充分证实.
研究的目的:
- 为了研究THRT与患者的死亡/发病率之间的关联,这些患者接受了为良性非毒性结节性喉进行甲状腺切除术或全甲状腺切除术.
主要方法:
- 一项追溯观察性研究使用了瑞典国家注册表.
- 在手术后的THRT患者和没有THRT患者之间的死亡率和发病率的比较.
- 包括在2006年7月至2017年12月期间为良性非毒性结节性关节手术的患者.
主要成果:
- 在5573名患者中,3929名患者接受了甲状腺外切除术,1644名患者接受了全甲状腺外切除术.
- 不接受THRT的甲状腺切除术患者的死亡风险比一般人群高31%.
- 多变量分析显示,与THRT患者相比,在没有THRT的甲状腺切除术患者中,死亡风险比率增加了65%.
结论:
- 没有术后THRT的甲状腺切除术患者面临着明显更高的死亡风险.
- 对良性疾病进行甲状腺切除术后的THRT似乎与死亡率降低有关.
- 在THRT的全甲状腺切除术患者或甲状腺切除术患者中没有观察到增加的死亡风险.
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