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通过下一代测序对新型HLA-DQB1*03:516等位基因的表征

Cheng Bian1, Zi-Hao Wang1, Zi-An Cheng1

  • 1Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan, China.

HLA
|February 19, 2024
PubMed
概括

一种新的人类白细胞抗原DQB1变体,HLA-DQB1*03:516,已被确定. 这种新等位基因与HLA-DQB1*03:03:02:03的区别在于,在第2个异位基因中单个G>A核酸替代.

关键词:
HLA-DQB1*03:516 这是一个很好的方法.基于NGS的类型化一个新型的等位基因

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.