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要正常化还是没有? :稀释拉塞尔蛇毒毒的时间测试
Yong Zhang1, Michael Creer1, Olajumoke O Oladipo1
1Department of Pathology and Laboratory Medicine, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA, US.
American journal of clinical pathology
|February 19, 2024
概括
稀释的拉塞尔蛇毒时间 (dRVVT) 屏幕/确认比率 (SCR) 的正常化并没有改变患者的狼抗凝剂 (LA) 状态. 这种规范化步骤在该人群中没有为方法内LA检测提供临床益处.
科学领域:
- 血液学 血液学 血液学
- 临床化学 临床化学
- 免疫学 免疫学 免疫学
背景情况:
- 狼抗凝剂 (LA) 测试对于诊断血栓性疾病至关重要.
- 稀释拉塞尔蛇毒时间 (dRVVT) 是用于LA检测的常见试验.
- 使用参考血进行dRVVT结果的规范化是一种标准化结果的潜在方法.
研究的目的:
- 为了比较非规范化和规范化的dRVVT屏幕/确认比率 (SCR).
- 评估正常化对狼抗凝剂 (LA) 状态确定的影响.
- 评估患者队列中正常化的临床实用性.
主要方法:
- 对464名接受dRVVT测试的患者进行了回顾性分析.
- 包括混合研究和对阳性查的确认测试.
- 在参考聚合血中测量dRVVT以实现正常化.
主要成果:
- 5.6%的样本通过非规范化和规范化方法证实LA阳性.
- 在非正常化和正常化的SCR之间,LA状态的100%一致性.
- 观察到SCR的统计学上显著差异,但偏差最小 (0.04).
结论:
- 在dRVVT SCR的正常化没有改变狼抗凝药的状态.
- 标准化没有为方法内LA检测提供额外的临床益处.
- 标准化可能更适用于方法间和实验室间的比较.
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